This study evaluates the effect of Amiodarone-Itraconazole (Amiozole) against two T. cruzi strains that are sensitive and naturally resistant to benznidazol (DA) treatment. The authors used integrated transcriptomic and ultrastructural analyses to determine the compound’s mechanisms of action.
This review encompasses 16 studies comprised of 4,974 dogs across five states and confirms the presence of canine T. cruzi infection in the U.S.
This study provides insights into T. cruzi transmission dynamics in southern Texas, demonstrating the active role of domestic dogs and wildlife in the local cycle of infection. Findings emphasize the need for continued surveillance and vector control measures to mitigate the risk of Chagas disease transmission.
Heart rate variability abnormalities are prominent across all dogs with Chagas disease. Analyzing these abnormalities can enhance early Chagas detection and treatment by identifying under-diagnosed cardiac dysfunction in dogs.
Vida teamed in a study that evaluated four different formulations of itraconazole and amiodarone. The study was published in the Wiley Journal of Veterinary Pharmacology and Therapeutics.
Vida Pharmacal participated in a study that monitored its treatment effectiveness using two real-time assays. Published in Sage Journals, August 5, 2019.
The purpose of the study reported here was to evaluate the clinical, serologic, parasitological, and histopathologic outcomes of dogs naturally infected with T cruzi and treated with a combination of itraconazole and amiodarone for 12 months.
Human pluripotent stem cells were differentiated into cardiomyocytes and infected with T. cruzi to test efficacy of combined ICZ and AMD dosage.
In the absence of systematic screening or surveillance, Chagas disease will continue to be under-diagnosed in the United States, and its prevalence underestimated. The coexistence of competent disease vectors and numerous mammalian reservoirs create risk for human transmission and infection.
Currently there is little data on the frequency of Trypanosoma cruzi infection in dogs in the United States. We aimed to fill the knowledge gap by conducting a study of the prevalence of Trypanosoma cruzi infection in dogs, with no indications for infection, visiting 4 veterinary clinics in the San Antonio region.
Recent biosurveillance findings at Joint Base San Antonio (JBSA), a large military installation located in south-central Texas, indicate the potential for vector-borne human Chagas disease. A cross-sectional study was conducted to determine the prevalence and seroprevalence of Trypanosoma cruzi infection in highest risk subpopulations on the installation, including students and instructors who work and sleep in triatomine-endemic field settings.
Trypanosomes were seen on a blood smear during a physical examination of a two-year-old male Pacific walrus (Odobenus rosmarus divergens). The walrus was at SeaWorld San Antonio on temporary loan from the Wildlife Conservation Society's New York Aquarium. The case report can be found here: